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Extravasated iodinated contrast media is hyperosmolar and toxic to the surrounding tissues. Most patients recover without sequelae but severe adverse events may occur. Extravasation produces an acute local inflammatory response that peaks at 24-48 hrs although ulceration and tissue necrosis may occur as early as 6 hours after the extravasation. Extravasation of a large volume of contrast material can produce a compartment syndrome. A plastic surgical consult is frequently not necessary and a reliance of .

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